Circulating levels of vitamin D, vitamin D receptor polymorphisms, and colorectal adenoma: a meta-analysis
نویسندگان
چکیده
منابع مشابه
Circulating levels of vitamin D, vitamin D receptor polymorphisms, and colorectal adenoma: a meta-analysis
Growing evidence suggests an elevated risk for colorectal neoplasia among individuals with low levels of vitamin D, the biological actions of which are mediated by the vitamin D receptor (VDR). To investigate the association among vitamin D status, VDR polymorphisms (FokI, and BsmI), and colorectal adenoma, we conducted a meta-analysis of nine studies of circulating levels of 25-hydroxyvitamin ...
متن کاملCirculating vitamin D metabolites, polymorphism in vitamin D receptor, and colorectal adenoma risk.
OBJECTIVE Vitamin D is a potential agent for the prevention of colorectal cancer possibly through mechanisms mediated by the vitamin D receptor (VDR). We investigated the association of circulating vitamin D metabolites and a genetic variant of the VDR gene with advanced colorectal adenoma, a precursor lesion of colorectal cancer. METHODS Cases with advanced adenoma of the distal large bowel ...
متن کاملVitamin D and prevention of colorectal adenoma: a meta-analysis.
BACKGROUND Vitamin D status is associated inversely with risk of colorectal cancer, but the association with adenoma risk is less clear. This meta-analysis examined the overall relationship between circulating (plasma or serum) 25-hydroxyvitamin D [25(OH)D], vitamin D intake (dietary, supplemental, or total), and colorectal adenoma incidence in published studies. METHODS A meta-analysis compo...
متن کاملMeta - analyses of vitamin D intake , 25 - hydroxyvitamin D status , vitamin D receptor 1 polymorphisms and colorectal cancer risk
3 Mathilde Touvier, Doris SM Chan, Rosa Lau, Dagfinn Aune, Rui Vieira, Darren C Greenwood, 4 Ellen Kampman, Elio Riboli, Serge Hercberg, Teresa Norat 5 Affiliations: 6 1 Department of Epidemiology and Biostatistics, School of public health, Imperial College London, 7 United Kingdom 8 2 Nutritional Epidemiology Unit, UREN (Inserm/Inra/Cnam/Paris13 University), CRNH IdF, Bobigny, 9 France 10 3 Bi...
متن کاملMeta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk.
BACKGROUND Our objective was to conduct a systematic review and meta-analysis of prospective studies on colorectal cancer (CRC) and vitamin D intake and 25-hydroxyvitamin D status, as part of the World Cancer Research Fund Continuous Update Project. We also aimed at conducting meta-analysis of all studies on CRC and vitamin D receptor (VDR) single-nucleotide polymorphisms. METHODS Relevant st...
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ژورنال
عنوان ژورنال: Nutrition Research and Practice
سال: 2011
ISSN: 1976-1457
DOI: 10.4162/nrp.2011.5.5.464